Antibody-Binding Proteins and Conjugates
Sigma Aldrich Fine Chemicals Biosciences SigmaMAb Antibody Drug Con5MG
SigmaMab Antibody Drug Conjugate (ADC) Mimic is a non-toxic drug mimic that is utilized as a standard for mass spectrometry and high performance liquid chromatography. The ADC Mimic conjugates SigmaMab (MSQC4) an IgG1 monoclonal antibody to dansyl fluorophores via an LC-SMCC crosslinker. This dansyl-LC-SMCC attachment serves as the substitution for the toxic payload of a real ADC. The ADC Mimic allows for safer and more consistent testing making it the optimal product over real ADCs. It is also a more affordable product compared to real ADCs. With the help of this non-toxic product LC-MS processes can be developed in a safer environment.
Cayman Chemical MethIcIlInsodIum salt 50mg
A semisynthetic penicillin antibiotic that can inhibit bacterial cell wall synthesis; used to study methicillin-resistance in S. aureus
Columbia Biosciences Corp GT ANTI-GST DYLIGHT 488 100UG
Goat Anti-GST IgG, primary antibody, conjugated to DyLight 488, 100ug. Microscopy, Flow Cytometry and Cell Based Assays
Cayman Chemical ArachIdIc AcIdodIum salt 50mg
A long-chain saturated fatty acid; inhibits fMLP-induced rabbit neutrophil aggregation at 5 μM
Cayman Chemical RIsedronatesodIum salt 500mg
An aminobisphosphonate and antimalarial agent that inhibits bone resorption; inhibits growth of P. falciparum in vitro (IC50 = 20.3 µM) and P. berghei in vivo (25 mg/kg for one week); inhibits protein prenylation by preventing transfer of a farnesyl pyrophosphate group to parasite proteins
Cayman Chemical TInptInsodIum salt 50mg
An atypical antidepressant; an agonist of MORs (EC50s = 194 and 641 nM for human and mouse receptors in a BRET assay for G protein activation; decreases immobility in the forced swim test in wild-type, but not MOR knockout mice at 30 mg/kg; increases locomotor activity at a dose of 30, but not 10 mg/kg, in the open field test; prevents increases in chronic restraint stress-induced GLT-1 expression in the rat hippocampal CA3 region at 10 mg/kg per day for 21 days
Cayman Chemical VU0155041sodIum salt 50mg
A selective positive allosteric modulator of mGluR4 (EC50 = 2.5 μM in a thallium flux assay); has no effect on radioligand binding at 67 G protein-coupled receptors, ion channels, and transporters; lacks antagonist activity at NMDA receptors in striatal medium spiny neurons at a concentration of 10 μM; decreases haloperidol-induced catalepsy and reverses reserpine-induced askinesias in rat models of Parkinson’s disease; restores social behavior in the Oprm-/- mouse model of autism; decreases anxiety-like behavior in the elevated plus maze in mice
Cayman Chemical ON-01910sodIum salt 25mg
A potent, non-ATP-competitive inhibitor of Plk1 (IC50 = 9 nM); induces apoptosis in a wide array of tumor cell lines (GI50 = 50-200 nM); active in vivo when administered intraperitoneally and synergizes with chemotherapeutic agents
Cayman Chemical EtIdronatesodIum salt 500mg
A non-nitrogenous bisphosphonate that binds to hydroxyapatite and reduces osteoclast proliferation, thereby inhibiting abnormal bone resorption
Cayman Chemical RhodamIn 101Inr salt 500mg
A bright fluorescent dye with excitation and emission maxima of 565 and 595 nm, respectively
Cayman Chemical ndocromIlsodIum salt 50mg
A mast cell stabilizer; inhibits IgE-induced histamine release from MC/3T3 cells preincubated with IL-2 at 10 µM; prevents EArly- and late-phase bronchoconstriction in a guinea pig model of asthma induced by ovalbumin; prevents conjunctival edema and erythema and reduces mast cell degranulation in a rat model of conjunctivitis at 2 mg/kg
